43AA Limited Human
TB-500
Synthetic 43-amino-acid peptide mirroring thymosin beta-4, studied for tissue repair, angiogenesis, and inflammation reduction.
In Plain English: Your body naturally produces a protein called thymosin beta-4 that rushes to sites of injury and helps coordinate healing — signalling cells to migrate, grow new blood vessels, and reduce inflammation. TB-500 is a lab-made copy of that same protein. Researchers study it in animal models of muscle, tendon, cardiac, and eye injuries to understand whether it can accelerate recovery and reduce scarring.
Research Maturity
Limited Human (800+ publications on Tb4; human evidence limited to Phase II trials+ Studies)
Quick Facts
Focus
Angiogenesis
Inflammation
Soft Tissue Repair
Route
IV
SubQ
Topical
Origin
Thymosin beta-4 is an endogenous peptide first isolated from calf thymus tissue in the 1960s; found at high concentrations in platelets, white blood cells, and most nucleated cells. TB-500 replicates the natural human sequence via solid-phase peptide synthesis.
Mechanism
Binds G-actin monomers 1:1, regulating cytoskeletal filament assembly. Promotes rapid cell migration and proliferation at injury sites. Activates ILK/Akt survival pathway, triggers NF-kB-dependent anti-inflammatory signalling, stimulates angiogenesis via PI3K/Akt/eNOS. Active motif: residues 17-23 (LKKTETQ).
Outcome
Wound-closure rate, infarct size and ejection fraction in cardiac models, corneal staining score, capillary density (angiogenesis), inflammatory cytokines (TNF-a, IL-6), and collagen-deposition/fibrosis markers.
Safety Flags & Warnings
Theoretical Tumour-Promotion Risk
WADA Prohibited (in & out of competition)
Injection Site Reactions
Adulteration / Purity Risk
Always consult a licensed physician. Research purposes only.
€13 / mg
