10AA Extensive Human
Gonadorelin (GnRH)
FDA-approved hypothalamic decapeptide that reboots the HPG axis — the most physiologically accurate tool for LH/FSH stimulation and fertility induction.
In Plain English: Gonadorelin is a synthetic copy of your body's gonadotropin-releasing hormone — the ten-amino-acid signal your hypothalamus sends to the pituitary every 90 minutes to keep testosterone, FSH, and sperm production running. Unlike testosterone injections (which shut the axis down), pulsatile gonadorelin keeps the whole chain active.
Research Maturity
Extensive Human (42,865 results on PubMed for 'gonadorelin' (verified 2026-05-04)+ Studies)
Quick Facts
Focus
Endocrine Diagnostics
Fertility & Reproduction
Route
IM
Intranasal
IV
SubQ
Origin
Endogenous neuropeptide first isolated by Schally and Guillemin (Nobel Prize 1977). Factrel (hydrochloride) FDA-approved 1978 for diagnostic use; Lutrepulse (acetate) for pulsatile ovulation induction. Both discontinued commercially; remains compoundable and widely used off-label.
Mechanism
Binds GnRH receptor type I on pituitary gonadotrophs, coupling Gq/G11 to PLC. IP3 triggers Ca2+ release; DAG activates PKC. Drives LH and FSH synthesis/exocytosis. CRITICAL: pulsatile (q60-120min) sustains secretion; continuous dosing causes receptor downregulation and suppression (Belchetz Paradigm 1978).
Outcome
Diagnostic: 100mcg IV elicits peak LH at 27-71 min. Therapeutic: 70-80% achieve spermatogenesis in 6-24 months (HH patients). Ovulation: 75% rate, 18%/cycle pregnancy rate. TRT adjunct: maintains testicular volume with <1% OHSS risk.
Safety Flags & Warnings
Anaphylaxis Risk
Receptor Desensitisation (Continuous Dosing)
Hormone-Dependent Tumour Contraindication
OHSS Risk (<1%)
Pregnancy Category X (Multi-Dose)
Always consult a licensed physician. Research purposes only.
€8.8 / mg
