3AA Limited Human
GHK Basic (Tripeptide-1)
The body's own regeneration signal — a copper-binding tripeptide that resets 4,000+ genes toward repair, youth, and resilience.
In Plain English: GHK is a tiny three-amino-acid peptide your body makes naturally. Blood levels peak at ~200 ng/mL in your 20s and drop 60% by age 60. When paired with copper (GHK-Cu), it tells fibroblasts to rebuild collagen and elastin, dials down chronic inflammation, and switches on antioxidant enzymes. Human trials confirm wrinkle reduction and skin thickening at 12 weeks.
Research Maturity
Limited Human (193 PubMed results for GHK-Cu / glycyl-histidyl-lysine+ Studies)
Quick Facts
Focus
Cosmetic Anti-Aging
Hair & Scalp
Skin Health
Route
Topical
Origin
Isolated from human plasma in 1973 by Loren Pickart. Naturally present in plasma, saliva, and urine. Levels decline from ~200 ng/mL at age 20 to ~80 ng/mL by 60. The copper complex forms spontaneously at physiological pH.
Mechanism
Delivers bioavailable Cu(II/I) into cells fuelling SOD and lysyl oxidase. Modulates 4,000+ genes — upregulates ECM repair, antioxidant, and anti-inflammatory while suppressing NF-kB, TNF-a, IL-6. Activates integrin and TGF-b signalling stimulating collagen I/III, elastin, and GAG synthesis.
Outcome
71-woman RCT: reduced wrinkle depth, increased skin density by week 12. 41-participant eye-cream study outperformed vitamin K. Post-laser: 25% faster epithelial recovery. Animal: 9-fold collagen increase, accelerated diabetic wound healing.
Safety Flags & Warnings
Topical: Clean Safety Record
Injectable: No Human PK Data
Wilson's Disease Contraindication
Angiogenesis / Cancer Caution
FDA Compounding Status (USA)
Always consult a licensed physician. Research purposes only.
€1.36 / mg
